[Relationship between aberrant FHIT transcripts and hepatocellular carcinoma]

Zhonghua Gan Zang Bing Za Zhi. 2003 Sep;11(9):550-1.
[Article in Chinese]

Abstract

Objective: To study the relationship between aberrant FHIT transcripts and hepatocellular carcinoma (HCC).

Methods: Reverse transcription-polymerase chain reaction (RT-PCR) and single strand conformational polymorphism (SSCP) assays were used to analyze the transcripts and mutations of FHIT gene in 24 matched tumorous tissues and para-tumorous tissues from patients with HCC and in 4 normal liver tissues.

Results: Aberrant FHIT transcripts were observed in 11 out of 24 (46%) tumorous tissues and in 2 (8%) of the matched para-tumorous tissues.

Conclusion: FHIT aberrant transcripts may play an important role in the pathogenesis of hepatocellular carcinoma.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Anhydride Hydrolases*
  • Carcinoma, Hepatocellular / genetics*
  • Humans
  • Liver Neoplasms / genetics*
  • Mutation
  • Neoplasm Proteins / genetics*
  • Polymorphism, Single-Stranded Conformational
  • RNA, Messenger / analysis
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • Neoplasm Proteins
  • RNA, Messenger
  • fragile histidine triad protein
  • Acid Anhydride Hydrolases