Stereospecific hydroxylation of (+)-cedrol by using human skin microbial flora Staphylococcus epidermidis

Mitsuo Miyazawa; Yumi Itsuzaki; Keiji Ishikawa; Kaname Ishisaka

doi:10.1080/1057563031000072541

Stereospecific hydroxylation of (+)-cedrol by using human skin microbial flora Staphylococcus epidermidis

Nat Prod Res. 2003 Oct;17(5):313-7. doi: 10.1080/1057563031000072541.

Authors

Mitsuo Miyazawa¹, Yumi Itsuzaki, Keiji Ishikawa, Kaname Ishisaka

Affiliation

¹ Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, 3-4-1, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan. miyazawa@apch.kindai.ac.jp

PMID: 14526908
DOI: 10.1080/1057563031000072541

Abstract

Microbial transformation of (+)-cedrol was investigated by using Staphylococcus epidermidis and found that stereospecific hydroxylation of (+)-cedrol occurred at the C-3 position to form (+)-(3S)-3-hydroxycedrol.

MeSH terms

Biotransformation
Humans
Hydroxylation
Molecular Conformation
Polycyclic Sesquiterpenes
Skin / microbiology
Staphylococcus epidermidis / enzymology*
Terpenes / metabolism*

Substances

Polycyclic Sesquiterpenes
Terpenes
cedrol