Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: evidence of enhanced in vitro activity

Dimitrios P Kontoyiannis; Russell E Lewis; Michail S Lionakis; Nathaniel D Albert; Gregory S May; Issam I Raad

doi:10.1016/s0732-8893(03)00136-6

Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: evidence of enhanced in vitro activity

Diagn Microbiol Infect Dis. 2003 Oct;47(2):415-9. doi: 10.1016/s0732-8893(03)00136-6.

Authors

Dimitrios P Kontoyiannis¹, Russell E Lewis, Michail S Lionakis, Nathaniel D Albert, Gregory S May, Issam I Raad

Affiliation

¹ Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA. dkontoyi@mdanderson.org

PMID: 14522515
DOI: 10.1016/s0732-8893(03)00136-6

Abstract

We investigated the in vitro activity of sequential itraconazole and caspofungin against 10 isolates of Aspergillus fumigatus. Previous exposure of A. fumigatus to itraconazole resulted in dose-dependent enhanced effects of caspofungin and vice versa. Our finding suggests a preferential role for azole-caspofungin sequential combinations and merits further in vivo investigation.

MeSH terms

Antifungal Agents / pharmacology*
Aspergillus fumigatus / drug effects*
Caspofungin
Drug Administration Schedule
Drug Interactions
Echinocandins
Humans
Itraconazole / pharmacology*
Lipopeptides
Microbial Sensitivity Tests / methods
Peptides / pharmacology*
Peptides, Cyclic*

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Peptides
Peptides, Cyclic
Itraconazole
Caspofungin