Abstract
A reinvestigation with a modified extraction procedure of Euphorbia decipiens resulted in the isolation and structure elucidation of three new myrsinane-type diterpene esters (1-3). The structures of compounds 1-3 were elucidated by spectroscopic data interpretation. Compound 1 showed inhibitory activity against prolyl endopeptidase (PEP), whereas compound 2 exhibited DNA-damaging activity in a mutant yeast bioassay.
MeSH terms
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Chryseobacterium / enzymology
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DNA Damage
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Euphorbia / chemistry*
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Iran
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Prolyl Oligopeptidases
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Saccharomyces cerevisiae / drug effects
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Serine Endopeptidases / drug effects
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Serine Endopeptidases / metabolism
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Serine Proteinase Inhibitors / chemistry
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Serine Proteinase Inhibitors / isolation & purification*
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Serine Proteinase Inhibitors / pharmacology
Substances
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3,5,15,17-O-tetraacetyl-7-O-benzoylcheiradone
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3,5,15,17-O-tetraacetyl-7-O-nicotinoylcheiradone
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3,5,17-O-triacetyl-7-O-benzoyl-15-hydroxycheiradone
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Diterpenes
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Serine Proteinase Inhibitors
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Serine Endopeptidases
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Prolyl Oligopeptidases