Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3451-4. doi: 10.1016/s0960-894x(03)00743-1.

Abstract

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that possess cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzodiazepines / chemical synthesis
  • Benzodiazepines / chemistry*
  • Benzodiazepines / pharmacology
  • Chrysenes / chemistry*
  • DNA / drug effects*
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry*
  • Pyrroles / pharmacology
  • Tumor Cells, Cultured

Substances

  • Chrysenes
  • Pyrroles
  • pyrrolo(2,1-c)(1,4)benzodiazepine
  • chrysene
  • Benzodiazepines
  • DNA