Abstract
Therapeutical doses of pyrimethamine are very close to toxic ones. Pyrimethamine is widely used in toxoplasmosis therapy. Hematological complications following pyrimethamine administration were seen in 4 patients treated for toxoplasmosis at our hospital in the last year. Pancytopenic syndrome was diagnosed in all four cases. Three patients recovered completely whereas ITP is persisting in one patient.
Publication types
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Case Reports
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Comparative Study
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English Abstract
MeSH terms
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Adult
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Combined Modality Therapy
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Dose-Response Relationship, Drug
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Female
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Humans
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Pancytopenia / chemically induced*
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Pancytopenia / therapy
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Pregnancy
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Pregnancy Complications, Hematologic / chemically induced*
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Pregnancy Complications, Hematologic / therapy
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Pregnancy Complications, Parasitic / blood
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Pregnancy Complications, Parasitic / drug therapy*
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Pyrimethamine / administration & dosage
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Pyrimethamine / adverse effects*
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Toxoplasmosis / blood
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Toxoplasmosis / complications
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Toxoplasmosis / drug therapy*