Discovery of a novel class of orally active, non-peptide angiotensin II antagonists

MeSH terms

• Administration, Oral
• Angiotensin II / antagonists & inhibitors*
• Animals
• Biphenyl Compounds / administration & dosage
• Biphenyl Compounds / chemical synthesis
• Biphenyl Compounds / pharmacokinetics
• Imidazoles / administration & dosage
• Imidazoles / chemical synthesis
• Imidazoles / pharmacokinetics
• Losartan
• Pyrimidines / administration & dosage
• Pyrimidines / chemical synthesis*
• Pyrimidines / pharmacokinetics
• Rats
• Rats, Inbred SHR
• Rats, Sprague-Dawley
• Structure-Activity Relationship
• Tetrazoles / administration & dosage
• Tetrazoles / chemical synthesis
• Tetrazoles / pharmacokinetics