Cyclosporin-induced nephrotoxicity and hypertension

Br J Hosp Med. 1992;48(8):483-5, 488-9.

Abstract

The use of cyclosporin in therapeutics is increasing. Unfortunately, cyclosporin has important detrimental effects on kidney function and blood pressure. Based on the pathogenesis of these side effects, different drug groups have been studied, but with variable success.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Animals
  • Atrial Natriuretic Factor / therapeutic use
  • Calcium Channel Blockers / therapeutic use
  • Clinical Trials as Topic
  • Cyclosporins / adverse effects*
  • Drug Evaluation, Preclinical
  • Humans
  • Hypertension / chemically induced*
  • Hypertension / drug therapy
  • Hypertension / epidemiology
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / drug therapy
  • Kidney Diseases / epidemiology
  • Misoprostol / therapeutic use

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Calcium Channel Blockers
  • Cyclosporins
  • Misoprostol
  • Atrial Natriuretic Factor