Abstract
The lipopolysaccharide (LPS)-induced release of cytokines from human monocytes can be prevented by previous interaction of serum with LPS. This inactivation is a function of lipoproteins. Here we show that LPS can be inactivated by low-density lipoproteins (LDL) as well as by high-density lipoproteins (HDL). The effects of heparin and EDTA on LPS inactivation by serum are also described.
MeSH terms
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Bacterial Toxins / immunology*
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Dose-Response Relationship, Drug
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Edetic Acid / pharmacology*
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Endotoxins*
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Enterotoxins / immunology*
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Heparin / pharmacology*
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Humans
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Lipopolysaccharides / immunology*
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Lipoproteins / pharmacology*
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Lipoproteins, HDL / pharmacology
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Lipoproteins, LDL / pharmacology
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Lipoproteins, VLDL / pharmacology
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Monocytes / drug effects*
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Monocytes / immunology
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Monokines / physiology*
Substances
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Bacterial Toxins
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Endotoxins
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Enterotoxins
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Lipopolysaccharides
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Lipoproteins
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Lipoproteins, HDL
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Lipoproteins, LDL
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Lipoproteins, VLDL
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Monokines
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salmonella toxin
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Heparin
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Edetic Acid