A simple and rapid method for screening transformant yeast colonies using PCR

Biotechniques. 1992 Nov;13(5):730-2, 735.

Abstract

A simple and rapid procedure for screening transformant yeast colonies is described. In this method, a trace amount of plasmid DNA is isolated from a small amount of yeast cell mass; then, the presence of the exogenous DNA in each yeast colony is detected by PCR amplification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cloning, Molecular / methods
  • DNA, Recombinant / analysis*
  • Electrophoresis, Agar Gel
  • Humans
  • Lactoferrin / genetics
  • Molecular Sequence Data
  • Plasmids*
  • Polymerase Chain Reaction
  • Saccharomyces cerevisiae / genetics*
  • Transformation, Genetic*

Substances

  • DNA, Recombinant
  • Lactoferrin