Abstract
The effects of vigabatrin were studied over a 6-month period in 43 patients with intractable epilepsy. Children with complex partial seizures, with or without secondary generalization, responded best with more than one-half achieving a greater than 50% reduction; generalized tonic-clonic seizures also improved but there was no significant change in absence or myoclonic seizures. Four patients are seizure-free on monotherapy with vigabatrin. The drug was well tolerated with few side effects.
MeSH terms
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Adolescent
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Aminocaproates / adverse effects
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Aminocaproates / therapeutic use*
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Anticonvulsants / adverse effects
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Anticonvulsants / therapeutic use*
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Child
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Child, Preschool
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Electroencephalography / drug effects*
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Epilepsies, Myoclonic / drug therapy
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Epilepsies, Partial / drug therapy
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Epilepsy / drug therapy*
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Epilepsy, Absence / drug therapy
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Epilepsy, Complex Partial / drug therapy
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Epilepsy, Tonic-Clonic / drug therapy
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Evoked Potentials / drug effects
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Female
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Humans
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Infant
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Male
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Retrospective Studies
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Spasms, Infantile / drug therapy*
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Vigabatrin
Substances
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Aminocaproates
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Anticonvulsants
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Vigabatrin