Abstract
Immunogenic and protective properties of VP40 and NP proteins of Marburg virus were studied. VP40 protein was shown to have insignificant immunogenicity and NP protein to be capable of protecting the animals from lethal infection by stimulation of cell-mediated immunity. No significant increase in the specific antibody level was found.
MeSH terms
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Animals
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Antibodies, Viral / blood
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Antibody Formation / immunology
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Electrophoresis, Polyacrylamide Gel
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Guinea Pigs
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Immunity, Cellular / immunology
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Immunoenzyme Techniques
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Lymphocyte Activation / immunology
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Marburgvirus / immunology*
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Marburgvirus / isolation & purification
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Molecular Weight
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Viral Proteins / analysis
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Viral Proteins / immunology*
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Viral Proteins / isolation & purification
Substances
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Antibodies, Viral
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Viral Proteins