Under mesopic conditions the contrast sensitivity of the central visual field is reduced as the result of a non-linear interaction between rod- and cone-mediated signals, each of which is capable of higher sensitivity in isolation. The interaction is produced only when the rod-mediated system is driven at flicker rates above 6 Hz. This finding bears upon how rod and cone signals are combined and therefore affects our interpretation of the significance of the relationship between retinal illuminance and both contrast sensitivity and temporal resolution.