Abstract
Background:
Previously, autologous Burkitt lymphoma-specific cytotoxic T-lymphocytes (CTL) were found to express the gamma and delta T-cell receptor and recognize tumor idiotype in a major histocompatibility complex (MHC) unrestricted fashion.
Methods:
In this study, the authors established autologous CTL lines and clones specific for a B-cell follicular lymphoma.
Results:
These CTL are tumor specific and inhibited by antiimmunoglobulin monoclonal antibodies, but unlike the Burkitt lymphoma-specific CTL, they are MHC restricted and express the alpha and beta T-cell receptor.
Conclusions:
These studies suggest that different B-cell lymphomas can induce CTL of different phenotypes and MHC restriction.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antibodies, Monoclonal / immunology
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CD3 Complex / analysis
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CD8 Antigens / analysis
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Cell Communication
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Cytotoxicity Tests, Immunologic
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Female
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Humans
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Immunotherapy
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Lymphoma, B-Cell / immunology*
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Lymphoma, B-Cell / therapy
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Lymphoma, Follicular / immunology*
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Lymphoma, Follicular / therapy
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Major Histocompatibility Complex / immunology*
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Receptors, Antigen, T-Cell, alpha-beta / analysis
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Remission Induction
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T-Lymphocytes, Cytotoxic / chemistry
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T-Lymphocytes, Cytotoxic / immunology*
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Tumor Cells, Cultured
Substances
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Antibodies, Monoclonal
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CD3 Complex
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CD8 Antigens
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Receptors, Antigen, T-Cell, alpha-beta