Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates

J Med Primatol. 1992 Jul;21(5):265-9.

Abstract

Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Monoclonal
  • Epitopes / immunology*
  • Gene Products, gag / immunology*
  • HIV / immunology*
  • HIV Core Protein p24 / immunology*
  • Simian Immunodeficiency Virus / immunology*

Substances

  • Antibodies, Monoclonal
  • Epitopes
  • Gag protein p27, Simian immunodeficiency virus
  • Gene Products, gag
  • HIV Core Protein p24