Abstract
Aprotinin (Trasylol; Bayer AG, Leverkusen, Germany), a protease inhibitor resembling or identical with Kunitz' pancreatic trypsin inhibitor, is said to have anticoagulant properties, but these are not clearly defined. The present study provides evidence that one action of aprotinin is inhibition of the activation of Hageman factor (factor XII).
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aprotinin / pharmacology*
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Blood Coagulation / drug effects*
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Ellagic Acid / antagonists & inhibitors
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Ellagic Acid / pharmacology
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Enzyme Activation / drug effects
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Factor X / metabolism
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Factor XII / metabolism*
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Glass
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Humans
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In Vitro Techniques
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Sulfoglycosphingolipids / antagonists & inhibitors
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Sulfoglycosphingolipids / pharmacology
Substances
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Sulfoglycosphingolipids
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Ellagic Acid
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Factor X
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Factor XII
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Aprotinin