Abstract
We report the expression of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) by breast cancer cells and normal breast tissue in vivo. N-nitrosomethyl-urea (NMU)-induced rat mammary tumors synthesize mRNAs for IGF-II and IGFBP-2, -3, and -4. In contrast, normal lactating breast contains only IGFBP-2 and IGF-II messages; IGFBP-3 and -4 mRNAs are absent in this tissue. IGF-I and IGFBP-1 mRNAs are not expressed in either NMU tumors or in normal breast. This is the first report of in vivo expression of IGFBPs and IGF-II messages in breast tumors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Blotting, Northern
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Carrier Proteins / genetics*
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Female
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Gene Expression Regulation*
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Gene Expression Regulation, Neoplastic*
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Insulin-Like Growth Factor Binding Proteins
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Mammary Glands, Animal / chemistry*
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Mammary Glands, Animal / metabolism
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Mammary Neoplasms, Experimental / chemistry
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Mammary Neoplasms, Experimental / genetics*
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Mammary Neoplasms, Experimental / metabolism
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RNA, Messenger / analysis*
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RNA, Messenger / genetics*
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RNA, Messenger / metabolism
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Rats
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Rats, Inbred Strains
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Somatomedins / genetics*
Substances
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Carrier Proteins
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Insulin-Like Growth Factor Binding Proteins
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RNA, Messenger
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Somatomedins