Maternal antihypertensive therapy with beta-blockers associated with poor outcome in very-low birthweight infants

R Kaaja; V Hiilesmaa; K Holma; A L Järvenpää

doi:10.1016/0020-7292(82)90128-x

Maternal antihypertensive therapy with beta-blockers associated with poor outcome in very-low birthweight infants

Int J Gynaecol Obstet. 1992 Jul;38(3):195-9. doi: 10.1016/0020-7292(82)90128-x.

Authors

R Kaaja¹, V Hiilesmaa, K Holma, A L Järvenpää

Affiliation

¹ First Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.

PMID: 1360421
DOI: 10.1016/0020-7292(82)90128-x

Abstract

The progress of 36 very-low birthweight (less than or equal to 1500 g) infants born to mothers with pregnancy-induced hypertonia or pre-eclampsia was studied. During the first year of life, 7 out of 19 infants died when the mothers' antihypertensive regimen included beta-blockers. Four of the deaths occurred within 15 days. There were no deaths in 16 infants whose mothers were treated with other antihypertensive treatment (P = 0.006). These results suggest that maternal beta-blocker therapy may have adverse effects on the very-low birthweight infants.

MeSH terms

Adrenergic beta-Antagonists / therapeutic use*
Female
Humans
Hypertension / drug therapy*
Infant
Infant Mortality*
Infant, Low Birth Weight*
Infant, Newborn
Male
Pre-Eclampsia / drug therapy*
Pregnancy
Pregnancy Complications, Cardiovascular / drug therapy*
Prenatal Exposure Delayed Effects*
Retrospective Studies

Substances

Adrenergic beta-Antagonists