Abstract
From the fresh latex of Euphorbia cooperi N E Br was isolated by partition and chromatographic methods, a diterpene ester 12-deoxyphorbol-16-isobutyrate-13-tigliate. The phorbol ester exhibited highly irritant activity on the mouse ear. Since skin irritancy is an indication of possible tumour promotion, the use of this plant as a medicine should be discouraged.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Carcinogens / analysis
-
Carcinogens / chemistry
-
Croton Oil / chemistry*
-
Dermatitis, Contact / etiology*
-
Drug Evaluation, Preclinical
-
Medicine, African Traditional*
-
Mice
-
Phorbol Esters / adverse effects*
-
Phorbol Esters / analysis
-
Phorbol Esters / chemistry
-
Plants, Medicinal / chemistry*
-
Plants, Toxic / chemistry*
-
Zimbabwe
Substances
-
Carcinogens
-
Phorbol Esters
-
Croton Oil