Kininogenase activity of rSMT3, a rat submandibular gland tonin

Agents Actions Suppl. 1992:38 ( Pt 3):23-30.

Abstract

rSMT3, a tonin like angiotensin II generating enzyme present in rSMG presents a potent oxytocic effect on the isolated rat uterus, which was blocked by a B2 bradykinin receptor antagonist. Under optimal conditions of pH, rSMT3 liberates kinin at rate 19-fold greater than angiotensin II.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / isolation & purification*
  • Angiotensin II / metabolism
  • Angiotensin II / pharmacology
  • Animals
  • Biological Assay
  • Blood Pressure / drug effects
  • Bradykinin / pharmacology
  • Chromatography, High Pressure Liquid
  • Female
  • In Vitro Techniques
  • Kallikreins / metabolism*
  • Kinetics
  • Kininogens / pharmacology
  • Male
  • Peptidyl-Dipeptidase A / metabolism*
  • Rats
  • Rats, Wistar
  • Saralasin / pharmacology
  • Submandibular Gland / enzymology*
  • Uterine Contraction / drug effects
  • Uterus / drug effects
  • Uterus / physiology

Substances

  • Kininogens
  • Angiotensin II
  • Peptidyl-Dipeptidase A
  • Kallikreins
  • Saralasin
  • Bradykinin