CD28 co-stimulation of T-cell-mediated cytotoxicity

Int J Cancer Suppl. 1992:7:33-5.

Abstract

Co-stimulation via the CD28 pathway permits small, resting human peripheral-blood T lymphocytes to mediate anti-CD3 monoclonal antibody (MAb) "re-directed" cytotoxicity. The effector cells are contained with the "memory" population of T lymphocytes, identified by expression of the CD45RO differentiation antigen. In this article, we review the requirements for initiating a cytolytic response and speculate on the physiological consequences of this process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antigens, CD / immunology*
  • Antigens, Differentiation, T-Lymphocyte / immunology*
  • CD28 Antigens
  • CD3 Complex / immunology*
  • Cytotoxicity, Immunologic*
  • Humans
  • Mast-Cell Sarcoma
  • Mice
  • Receptors, Cell Surface / immunology
  • T-Lymphocytes / immunology*
  • Tumor Cells, Cultured

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • CD28 Antigens
  • CD3 Complex
  • Receptors, Cell Surface