3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex

J Med Chem. 1992 Sep 4;35(18):3423-5. doi: 10.1021/jm00096a019.

Authors

L A McQuaid¹, E C Smith, D Lodge, E Pralong, J H Wikel, D O Calligaro, P J O'Malley

Affiliation

¹ Lilly Research Laboratories, Division of Eli Lilly and Company Corporate Center, Indianapolis, Indiana 46285.

PMID: 1326635
DOI: 10.1021/jm00096a019

No abstract available

MeSH terms

Animals
Binding Sites
Glycine / antagonists & inhibitors*
Glycine / metabolism
Quinolones / pharmacology*
Rats
Receptors, N-Methyl-D-Aspartate / drug effects*
Structure-Activity Relationship
Strychnine / pharmacology*

Substances

Quinolones
Receptors, N-Methyl-D-Aspartate
Strychnine
Glycine