Abstract
This study determined the frequency of multiple viral (HIV-1, HHV-6, and CMV) infections in 26 retinas from 16 AIDS patients. Of the 12 retinas of 26 that tested positive for HIV-1 DNA sequences, seven also were positive for HHV-6 DNA sequences. Four of these seven retinas were culture positive for HIV-1 and two of the four contained CMV DNA sequences and antigens. Using RNA probes, HIV-1 and HHV-6 transcriptional activity was demonstrated in two of the four HIV-1 culture positive retinas. These retinas also contained CMV DNA sequences and antigens. The results demonstrate that more than 35% of AIDS patients suffer from at least two simultaneous viral infections and 15% suffer from three viral infections. The presence of transcriptional activity of HIV-1 and HHV-6 suggests an active infection.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / microbiology
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Acquired Immunodeficiency Syndrome / pathology
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Antibodies, Viral / analysis
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Base Sequence
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Cytomegalovirus / genetics
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Cytomegalovirus / immunology
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Cytomegalovirus / isolation & purification
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Cytomegalovirus / ultrastructure
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Cytomegalovirus Infections / microbiology
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Cytomegalovirus Infections / pathology
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DNA, Viral / genetics
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Eye Infections, Viral / microbiology*
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Gene Expression Regulation, Viral
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HIV Infections / microbiology*
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HIV-1 / genetics*
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HIV-1 / immunology
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HIV-1 / isolation & purification
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HIV-1 / ultrastructure
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Herpesviridae Infections / microbiology*
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Herpesvirus 6, Human / genetics*
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Herpesvirus 6, Human / immunology
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Herpesvirus 6, Human / isolation & purification
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Herpesvirus 6, Human / ultrastructure
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Humans
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Molecular Sequence Data
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RNA Probes
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Retinal Diseases / microbiology*
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Retinal Diseases / pathology
Substances
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Antibodies, Viral
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DNA, Viral
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RNA Probes