[Cortical dysplasia as an epileptogenic focus: reduced binding of 123I-iomezanil with barely perceptible 99mTc-HMPAO SPECT]

Nuklearmedizin. 1992 Aug;31(4):142-4.
[Article in German]

Abstract

In cortical areas associated with an epileptic focus, there is, in the majority of cases, a correlation between decreased benzodiazepine (Bz) receptor binding, detectable with 123I-Iomazenil, and decreased blood flow. A patient with focal epilepsy due to a localized abnormality in cortical differentiation is presented who showed a marked focal decrease in Bz receptor binding and a normal 99mTc-HMPAO SPECT. Based on this case the relation between blood flow and Bz receptor binding in epileptic foci is discussed.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Cortex / abnormalities*
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / metabolism
  • Epilepsies, Partial / diagnostic imaging
  • Epilepsies, Partial / etiology*
  • Epilepsies, Partial / metabolism
  • Female
  • Flumazenil / analogs & derivatives*
  • Humans
  • Iodine Radioisotopes
  • Middle Aged
  • Organotechnetium Compounds*
  • Oximes*
  • Receptors, GABA-A / metabolism*
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Iodine Radioisotopes
  • Organotechnetium Compounds
  • Oximes
  • Receptors, GABA-A
  • Technetium Tc 99m Exametazime
  • Flumazenil
  • iomazenil