Role of prostaglandin E2 (PGE2) on the corticotropin-releasing hormone (CRH)-induced ACTH release in healthy men

S Zacharieva; A M Borissova; K Andonova; I Stoeva; P Matrozov

doi:10.1055/s-2007-1003327

Role of prostaglandin E2 (PGE2) on the corticotropin-releasing hormone (CRH)-induced ACTH release in healthy men

Horm Metab Res. 1992 Jul;24(7):336-8. doi: 10.1055/s-2007-1003327.

Authors

S Zacharieva¹, A M Borissova, K Andonova, I Stoeva, P Matrozov

Affiliation

¹ Institute of Endocrinology and Gerontology, Medical Academy, Sofia, Bulgaria.

PMID: 1325403
DOI: 10.1055/s-2007-1003327

Abstract

The effect of PGE2 on ACTH and cortisol responses to CRH was studied in 6 healthy men who received CRH i.v. during either saline or PGE2 infusions which were started 60 min. before testing. ACTH and cortisol responses to CRH were greater during PGE2 infusion compared to the control study. The results indicate that PGE2 positively modulates CRH-induced ACTH secretion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adrenocorticotropic Hormone / blood*
Adult
Corticotropin-Releasing Hormone / pharmacology*
Dinoprostone / pharmacology*
Humans
Hydrocortisone / blood
Male

Substances

Adrenocorticotropic Hormone
Corticotropin-Releasing Hormone
Dinoprostone
Hydrocortisone