Three new systems were developed for trapping [11C]CO2 from high flow rate nitrogen gas streams and the trapping efficiency was determined for each trap design. The results of this study indicate that both the stainless steel shot and stainless steel frit systems yield high trapping efficiencies under the range of flow rates evaluated (400-3600 sccm) and may prove to be alternatives to the traditional stainless steel/copper coiled tubing or molecular sieve trapping systems in common use.