Cytomegalovirus (CMV) pneumonitis in AIDS patients: the result of intensive CMV replication?

Eur Respir J. 1992 Mar;5(3):362-4.

Abstract

We report a case of fatal pulmonary disease in a patient infected with human immunodeficiency virus (HIV), where cytomegalovirus (CMV) was the only causative agent identified in the lungs at autopsy. The most prominent histopathological features were numerous interalveolar cells containing CMV inclusion bodies combined with scanty signs of inflammation. We propose that the lung damage caused by CMV in acquired immune deficiency syndrome (AIDS) patients is a direct consequence of cytopathogenic effects of the virus related to the extent of active virus replication.

Publication types

  • Case Reports

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / microbiology
  • Acquired Immunodeficiency Syndrome / pathology
  • Adult
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus / pathogenicity*
  • Cytomegalovirus / physiology
  • Cytomegalovirus Infections / etiology*
  • Cytomegalovirus Infections / microbiology
  • Cytomegalovirus Infections / pathology
  • Cytopathogenic Effect, Viral / physiology
  • Humans
  • Inclusion Bodies, Viral / ultrastructure
  • Lung / microbiology*
  • Lung / pathology
  • Lung / ultrastructure
  • Male
  • Opportunistic Infections / etiology*
  • Opportunistic Infections / microbiology
  • Opportunistic Infections / pathology
  • Pneumonia, Viral / etiology*
  • Pneumonia, Viral / microbiology
  • Pneumonia, Viral / pathology
  • Virus Replication / physiology*