[Sensitivity test to chemotherapeutic agents and cytotoxicic test against immuno-effecter cells of established malignant fibrous histiocytoma cell line]

Nihon Jibiinkoka Gakkai Kaiho. 1992 Feb;95(2):207-13. doi: 10.3950/jibiinkoka.95.207.
[Article in Japanese]

Abstract

A cell line was established from a patient with malignant fibrous histiocytoma, which had originated in the maxillary sinus. Using this cell line, sensitivity to chemotherapeutic agents and cytotoxicity against various immunoeffecter cells were tested.

Results: This MFH cell line was sensitive in some degree to adriamycin, 5-fluorouracil, cisplatin, peplomycin, and methotrexate at high doses, but insensitive to mitomycin-C, vincristine and cyclophosphamide. Furthermore, this cell line showed no sensitivity to cytolytic cytokines, such as tumor necrosis factor-alpha and interferon-gamma. Lymphokine activated killer (LAK) cells and lymphokine activated tumor infiltrating lymphocytes (LA-TIL), induced by culture of peripheral blood lymphocytes and TIL respectively with rIL-2 showed high NK and LK activities and remarkable anti-autologous tumor ability.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Cytotoxicity Tests, Immunologic
  • Drug Screening Assays, Antitumor
  • Histiocytoma, Benign Fibrous / immunology
  • Histiocytoma, Benign Fibrous / pathology*
  • Humans
  • Killer Cells, Lymphokine-Activated / immunology*
  • Lymphocytes, Tumor-Infiltrating / immunology*
  • Male
  • Maxillary Sinus Neoplasms / immunology
  • Maxillary Sinus Neoplasms / pathology
  • Middle Aged
  • Tumor Cells, Cultured / drug effects
  • Tumor Cells, Cultured / pathology

Substances

  • Antineoplastic Agents