Abstract
Myeloid differentiation (MyD) primary response and growth arrest DNA-damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45a MyD118/Gadd45b, GADD45g, MyD116/Gadd34) genes, that have been cloned by virtue of being coordinately induced upon the onset of terminal myeloid differentiation. This review delineates the role MyD genes were found to play in blood cell development, where they function as positive regulators of terminal differentiation, lineage specific blood cell development, and control of blood cell homeostasis, including growth inhibition and apoptosis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Differentiation
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Apoptosis
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Cell Differentiation
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GADD45 Proteins
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Hematopoiesis / genetics*
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Humans
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Intracellular Signaling Peptides and Proteins
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Leukemia, Myeloid / genetics
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Myeloid Cells / immunology
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Myeloid Cells / metabolism
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Myeloid Cells / pathology
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Protein Phosphatase 1
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Proteins / genetics
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Signal Transduction
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Transcription Factors / physiology*
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Transcriptional Activation
Substances
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Antigens, Differentiation
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Cell Cycle Proteins
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Intracellular Signaling Peptides and Proteins
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Proteins
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Transcription Factors
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PPP1R15A protein, human
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Protein Phosphatase 1