Abstract
The immunostaining for tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) after intranigral infusion of 6-hydroxydopamine (6-OHDA, 6 microg/side) was analyzed in ovariectomized adult female Wistar rats. Estrogen replacement for 52 days (400-microg 17-beta-estradiol capsules) did not prevent the loss of TH-immunoreactive cells induced by 6-OHDA in the SNpc. This result indicates that the neuroprotective effect of dopaminergic mesencephalic cells is not observed with long-term estrogen replacement.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dopamine / metabolism
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Estrogens / pharmacology*
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Female
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Neurons / drug effects*
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Neurons / metabolism
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Neuroprotective Agents / pharmacology*
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Oxidopamine / pharmacology
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Parkinsonian Disorders / drug therapy*
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Parkinsonian Disorders / metabolism
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Parkinsonian Disorders / physiopathology
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Rats
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Rats, Wistar
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Substantia Nigra / drug effects*
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Substantia Nigra / pathology
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Substantia Nigra / physiopathology
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Treatment Failure
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Tyrosine 3-Monooxygenase / metabolism
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Ventral Tegmental Area / drug effects
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Ventral Tegmental Area / pathology
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Ventral Tegmental Area / physiopathology
Substances
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Estrogens
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Neuroprotective Agents
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Oxidopamine
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Tyrosine 3-Monooxygenase
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Dopamine