Cytotoxic activity of tetraprenylphenols related to suillin, an antitumor principle from Suillus granulatus

J Nat Prod. 1992 Dec;55(12):1772-5. doi: 10.1021/np50090a010.

Abstract

Cytotoxic activity against three tumor cell lines (KB, P-388, and NSCLC-N6) has been determined for 14 natural and semisynthetic tetraprenylphenols. Structure-activity relationships have been examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Basidiomycota / chemistry*
  • Cell Survival / drug effects
  • Diterpenes / pharmacology*
  • Humans
  • KB Cells / drug effects
  • Leukemia P388 / pathology
  • Phenols / pharmacology*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Phenols
  • suillin