HLA typing and Parkinson's disease

Eur Neurol. 2003;50(2):64-8. doi: 10.1159/000072500.

Abstract

Idiopathic Parkinson's disease (IPD) is a neurodegenerative disorder of unknown aetiology. Several antigens have been associated with IPD using serological methods. We systematically analysed HLA class I and II alleles in 45 German Caucasian IPD patients using sequence-specific oligonucleotides and sequence-specific primer technology. Applying Bonferroni adjusted p values, we demonstrate a statistically significant increase of the DQB1*06 allele (p = 0.002) in IPD which may indicate an association between IPD and the immune system. Alternatively, HLA alleles might be in linkage disequilibrium with genes located next to the HLA locus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Gene Frequency*
  • Genetic Predisposition to Disease
  • Germany
  • HLA-DQ Antigens / genetics*
  • Histocompatibility Antigens Class I / analysis
  • Histocompatibility Antigens Class I / genetics*
  • Histocompatibility Antigens Class II / analysis
  • Histocompatibility Antigens Class II / genetics*
  • Histocompatibility Testing
  • Humans
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Parkinson Disease / genetics*
  • Polymerase Chain Reaction
  • White People / genetics*

Substances

  • HLA-DQ Antigens
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II