Are smoking and chlamydial infection risk factors for CIN? Different results after adjustment for HPV DNA and antibodies

Br J Cancer. 2003 Sep 1;89(5):831-3. doi: 10.1038/sj.bjc.6601220.

Abstract

To identify the risk factors for cervical intraepithelial neoplasia (CIN), we reanalysed the data from our previous case-control study by adjusting for human papillomavirus (HPV) antibodies. Unlike our previous study based only on HPV DNA, smoking and Chlamydia trachomatis infection were revealed as significant risk factors for CIN after adjustment for HPV antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / blood
  • Case-Control Studies
  • Chlamydia Infections / complications*
  • Confounding Factors, Epidemiologic
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Logistic Models
  • Papillomaviridae / genetics
  • Papillomaviridae / immunology
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / immunology
  • Polymerase Chain Reaction
  • Risk Factors
  • Smoking / adverse effects*
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / immunology*
  • Uterine Cervical Dysplasia / epidemiology*
  • Uterine Cervical Dysplasia / virology
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / virology

Substances

  • Antibodies, Viral