Comparison of three different purification methods for the routine preparation of [11C] Metomidate

Markus Mitterhauser; Wolfgang Wadsak; Oliver Langer; Joern Schmaljohann; Georg Zettinig; Robert Dudczak; Helmut Viernstein; Kurt Kletter

doi:10.1016/s0969-8043(03)00168-4

Comparison of three different purification methods for the routine preparation of [11C] Metomidate

Appl Radiat Isot. 2003 Aug-Sep;59(2-3):125-8. doi: 10.1016/s0969-8043(03)00168-4.

Authors

Markus Mitterhauser¹, Wolfgang Wadsak, Oliver Langer, Joern Schmaljohann, Georg Zettinig, Robert Dudczak, Helmut Viernstein, Kurt Kletter

Affiliation

¹ Department of Nuclear Medicine, University of Vienna, AKH Wein, Waehringer Guertel 18-20, 1090 Vienna, Austria. markus.mitterhauser@akh-wien.ac.at

PMID: 12941500
DOI: 10.1016/s0969-8043(03)00168-4

Abstract

PET with (R)-[O-methyl-11C] metomidate ([11C] MTO) is an attractive method for the characterisation of adrenal masses discriminating lesions of adrenal cortical origin from noncortical lesions. [11C] MTO was prepared by the reaction of [11C] methyliodide with the corresponding free acid. Three purification methods have been compared. The method of choice uses preparative HPLC with a ready-to-use weak acidic solvent.

Publication types

Comparative Study
Evaluation Study
Validation Study

MeSH terms

Adrenal Gland Neoplasms / diagnostic imaging
Carbon Radioisotopes / chemistry
Carbon Radioisotopes / isolation & purification
Chromatography, High Pressure Liquid
Etomidate / analogs & derivatives*
Etomidate / chemical synthesis*
Etomidate / isolation & purification*
Isotope Labeling / methods*
Quality Control
Tomography, Emission-Computed / methods*

Substances

Carbon Radioisotopes
metomidate
Etomidate