Abstract
Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Blood Platelets / immunology*
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Blood Platelets / physiology
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Case-Control Studies
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Cytotoxicity, Immunologic / genetics*
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Granzymes
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Humans
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Interferon-gamma / genetics
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Membrane Glycoproteins / genetics
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Oligonucleotide Array Sequence Analysis
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Perforin
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Pore Forming Cytotoxic Proteins
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Purpura, Thrombocytopenic, Idiopathic / blood
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Purpura, Thrombocytopenic, Idiopathic / genetics*
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Purpura, Thrombocytopenic, Idiopathic / immunology*
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Receptors, Immunologic / genetics
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Receptors, Interleukin-2 / genetics
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Receptors, KIR
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Serine Endopeptidases / genetics
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T-Lymphocytes, Cytotoxic / immunology*
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T-Lymphocytes, Cytotoxic / physiology
Substances
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Membrane Glycoproteins
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Pore Forming Cytotoxic Proteins
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Receptors, Immunologic
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Receptors, Interleukin-2
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Receptors, KIR
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Perforin
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Interferon-gamma
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GZMB protein, human
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Granzymes
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Serine Endopeptidases