Nicotinamide ribosyl uptake mutants in Haemophilus influenzae

Infect Immun. 2003 Sep;71(9):5398-401. doi: 10.1128/IAI.71.9.5398-5401.2003.

Abstract

The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Base Sequence
  • Biological Transport, Active
  • DNA, Bacterial / genetics
  • Genes, Bacterial*
  • Genetic Complementation Test
  • Haemophilus Infections / etiology
  • Haemophilus Infections / microbiology
  • Haemophilus influenzae / genetics*
  • Haemophilus influenzae / metabolism*
  • Kinetics
  • Mutation*
  • Niacinamide / analogs & derivatives*
  • Niacinamide / metabolism*
  • Pyridinium Compounds

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • NadV protein, Haemophilus ducreyi
  • Pyridinium Compounds
  • nicotinamide-beta-riboside
  • Niacinamide