Abstract
3-Amino-[2'-substitutedaryl-3'-substitutedarylaminomethylene-2',3'- dihydro-1',5'-benzoxazepin-4'-yl]-2-methyl-quinazolin-4(3H)-ones 11-18 and 3-amino-[2'-substituted aryl-3'-substitutedaryl-azo-2',3'- dihydro-1',5'-benzoxazepin-4'-yl]-2-methyl-quinazolin-4(3H)-ones 19-26 were synthesized from 3-amino-[2'-substitutedaryl-2',3'-dihydro-1',5'- benzoxazepin-4'-yl]-2-methyl-quinazolin-4(3H)-ones 7-10 by Mannich's reaction and by diazotisation, respectively, on the 3rd position of the benzoxazepine ring of the compounds 7-10. The newly synthesized compounds showed potent antipsychotic and anticonvulsant activities.
MeSH terms
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Amphetamine / antagonists & inhibitors
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Animals
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / pharmacology*
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Anticonvulsants / toxicity
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Antipsychotic Agents / chemical synthesis*
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Antipsychotic Agents / pharmacology*
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Antipsychotic Agents / toxicity
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Catalepsy / chemically induced
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Central Nervous System Stimulants / antagonists & inhibitors
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Chemical Phenomena
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Chemistry, Physical
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Chlorpromazine / pharmacology
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Electroshock
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Female
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Hypnotics and Sedatives / chemical synthesis
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Hypnotics and Sedatives / pharmacology
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Indicators and Reagents
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Oxazepines / chemistry*
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Oxazepines / pharmacology*
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Pentobarbital / pharmacology
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Quinazolines / chemistry*
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Quinazolines / pharmacology*
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Rats
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Sleep / drug effects
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Spectrophotometry, Infrared
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Structure-Activity Relationship
Substances
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Anticonvulsants
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Antipsychotic Agents
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Central Nervous System Stimulants
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Hypnotics and Sedatives
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Indicators and Reagents
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Oxazepines
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Quinazolines
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Amphetamine
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Pentobarbital
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Chlorpromazine