Abstract
Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4(+) T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4(+) T cells play a role in the pathogenesis of HAM/TSP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / immunology*
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CD4-Positive T-Lymphocytes / virology*
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Carrier State / immunology
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Enterotoxins / pharmacology
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Human T-lymphotropic virus 1 / immunology*
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Human T-lymphotropic virus 1 / isolation & purification
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Humans
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In Vitro Techniques
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Interferon-gamma / biosynthesis
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Interleukin-2 / biosynthesis*
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Lymphotoxin-alpha / biosynthesis
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Paraparesis, Tropical Spastic / etiology
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Paraparesis, Tropical Spastic / immunology*
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Proviruses / immunology
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Proviruses / isolation & purification
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Tetradecanoylphorbol Acetate / pharmacology
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Tumor Necrosis Factor-alpha / biosynthesis*
Substances
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Enterotoxins
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Interleukin-2
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Lymphotoxin-alpha
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Tumor Necrosis Factor-alpha
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enterotoxin B, staphylococcal
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Interferon-gamma
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Tetradecanoylphorbol Acetate