Abstract
The babA2 and cagA genes were investigated in 208 Brazilian Helicobacter pylori strains. A strong association between babA2 and duodenal ulcer or gastric carcinoma was observed, even after adjusting for confounding factors, such as age, gender, and cagA status. cagA-positive strains were also independently associated with H. pylori-related diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adhesins, Bacterial / genetics
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Adult
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Aged
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Aged, 80 and over
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Analysis of Variance
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Antigens, Bacterial / genetics*
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Bacterial Proteins / genetics*
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Brazil / epidemiology
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Carrier Proteins / genetics
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Duodenal Ulcer / epidemiology
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Duodenal Ulcer / microbiology*
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Female
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Gastritis / microbiology
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Helicobacter Infections / complications
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Helicobacter pylori / genetics*
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Helicobacter pylori / pathogenicity
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Humans
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Male
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Middle Aged
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Multivariate Analysis
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Stomach Neoplasms / epidemiology
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Stomach Neoplasms / microbiology*
Substances
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Adhesins, Bacterial
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Antigens, Bacterial
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BabA protein, Helicobacter pylori
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Bacterial Proteins
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Carrier Proteins
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cagA protein, Helicobacter pylori