Abstract
Fifty-six young central obese patients were investigated to evaluate relationships between soluble E-selectin (sE-S), angiotensin-converting enzyme (ACE) gene polymorphism, left ventricular function and structure, and carotid morphology by determination of sE-S and ACE genotypes. Our results indicated that central obese subjects with concomitant higher levels of sE-S and ACE DD genotype may be characterized by early cardiovascular alterations and then considered a particular subset of subjects at higher risk of cardiovascular disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alleles
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Arteriosclerosis / genetics
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Arteriosclerosis / pathology
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Blood Pressure
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Body Mass Index
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Cardiovascular Diseases / genetics*
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Cardiovascular Diseases / pathology*
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Carotid Arteries / physiology
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E-Selectin / metabolism*
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Echocardiography
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Female
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Genotype
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Glucose Tolerance Test
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Heart / physiology
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Hemodynamics / genetics
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Hemodynamics / physiology
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Humans
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Insulin / blood
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Isoenzymes / genetics*
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Isoenzymes / metabolism*
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Male
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Obesity / genetics*
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Obesity / metabolism
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Obesity / pathology*
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Peptidyl-Dipeptidase A / genetics*
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Peptidyl-Dipeptidase A / metabolism*
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Regression Analysis
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Risk Factors
Substances
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E-Selectin
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Insulin
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Isoenzymes
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Peptidyl-Dipeptidase A