Abstract
A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent.
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Disease Progression
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Female
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Fluorouracil / administration & dosage
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Humans
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Infusions, Intravenous
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Leucovorin / administration & dosage
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Male
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Middle Aged
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Neoplasm Metastasis
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Neuroendocrine Tumors / drug therapy*
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Neuroendocrine Tumors / pathology
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Retrospective Studies
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Streptozocin / administration & dosage
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Survival Analysis
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Treatment Outcome
Substances
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Streptozocin
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Leucovorin
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Fluorouracil