[Cerebokrast as a corrector of postischemic phenomena in acute transient cerebral ischemia]

Biull Eksp Biol Med. 1992 Oct;114(10):378-80.
[Article in Russian]

Abstract

Acute cerebral ischemia in cats (both carotid arteries occlusion during 30 min after permanent occlusion of both vertebral arteries) was accompanied by postischemic hypoperfusion and hypo-oxygenation of the cerebral tissue. Intravenous infusion of cerebrocrast (1 micrograms.kg-1.min-1 during 60 min) prevented manifestation of the postischemic phenomena. Antihypoxic effect of cerebrocrast involved the cerebral blood flow increase, brain oxygen consumption lowering and Hb-O2-affinity decrease.

Publication types

  • English Abstract

MeSH terms

  • Acute Disease
  • Animals
  • Brain / drug effects
  • Brain / metabolism
  • Calcium Channel Blockers / therapeutic use*
  • Cats
  • Dihydropyridines / therapeutic use*
  • Drug Evaluation, Preclinical
  • Female
  • Hemodynamics / drug effects
  • Ischemic Attack, Transient / drug therapy*
  • Ischemic Attack, Transient / physiopathology
  • Male
  • Oxygen Consumption / drug effects
  • Time Factors
  • Vasodilator Agents / therapeutic use*

Substances

  • Calcium Channel Blockers
  • Dihydropyridines
  • Vasodilator Agents
  • 2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine