Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells

Chem Commun (Camb). 2003 Jul 21:(14):1718-9. doi: 10.1039/b303294a.

Abstract

A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / toxicity*
  • Apoptosis / drug effects*
  • Apoptosis / physiology
  • DNA / chemistry*
  • Female
  • Gold Compounds / chemistry
  • Gold Compounds / toxicity*
  • Humans
  • Porphyrins / chemistry
  • Porphyrins / toxicity*
  • Protein Binding / drug effects
  • Protein Binding / physiology
  • Tumor Cells, Cultured
  • Uterine Cervical Neoplasms / drug therapy
  • Uterine Cervical Neoplasms / metabolism

Substances

  • Antineoplastic Agents
  • Gold Compounds
  • Porphyrins
  • DNA