Excess electron transfer in flavin-capped, thymine dimer-containing DNA hairpins

Chem Commun (Camb). 2003 Jul 21:(14):1632-3. doi: 10.1039/b303805j.

Abstract

The transfer of an excess electron through DNA was investigated with DNA hairpins, which contain a flavin cap functioning as an electron donor. A thymine dimer with an open backbone acts as the electron acceptor. The dimer translates the electron capture into a strand break, which is readily detectable by HPLC. Analysis of four hairpins, in which the distance between the flavin donor and the dimer acceptor was systematically increased, revealed a flat distance dependence of the repair efficiency supporting the view that excess electrons hop through DNA using intermediate A-T base pairs as temporary charge carriers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / analysis*
  • DNA / chemistry
  • Electron Transport* / physiology
  • Flavins / analysis*
  • Flavins / chemistry
  • Pyrimidine Dimers / analysis*
  • Pyrimidine Dimers / chemistry

Substances

  • Flavins
  • Pyrimidine Dimers
  • DNA