Abstract
The chemical attachment of oligonucleotides on glass slides has been achieved using oxime bond formation. This method has been shown very efficient by comparison with the attachment of amino-oligonucleotides via reductive amination.
MeSH terms
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Amination
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Glass / chemistry*
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Image Processing, Computer-Assisted
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In Situ Hybridization, Fluorescence
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Models, Chemical
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Oligonucleotides / chemical synthesis*
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Oxidation-Reduction
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Oximes / chemical synthesis*
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Silanes / chemistry
Substances
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Oligonucleotides
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Oximes
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Silanes