Abstract
Optimization and solid-phase synthesis of new spiroimidazolidinone derivatives as highly functionalized templates is reported. The synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives was performed on SynPhase lanterns from dipeptides anchored on the solid support and N-protected piperidone. A library of 180 discrete compounds was prepared.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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Combinatorial Chemistry Techniques / methods*
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Gas Chromatography-Mass Spectrometry
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
Substances
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Imidazoles
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Spiro Compounds