Genomic approaches to identifying transcriptional regulators of osteoblast differentiation

Genome Biol. 2003;4(7):222. doi: 10.1186/gb-2003-4-7-222. Epub 2003 Jul 1.

Abstract

Recent microarray studies of mouse and human osteoblast differentiation in vitro have identified novel transcription factors that may be important in the establishment and maintenance of differentiation. These findings help unravel the pattern of gene-expression changes that underly the complex process of bone formation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Gene Expression Profiling
  • Genomics
  • Humans
  • Mice
  • Models, Biological
  • Oligonucleotide Array Sequence Analysis
  • Osteoblasts / metabolism*
  • Stem Cells / metabolism
  • Stem Cells / physiology
  • Transcription Factors / biosynthesis
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Transcription, Genetic

Substances

  • Transcription Factors