In vitro transmission and antigenicity of a retrovirus isolated from a multiple sclerosis patient

H Perron; B Gratacap; B Lalande; O Genoulaz; A Laurent; C Geny; M Mallaret; P Innocenti; E Schuller; P Stoebner

doi:10.1016/s0923-2516(06)80122-6

In vitro transmission and antigenicity of a retrovirus isolated from a multiple sclerosis patient

Res Virol. 1992 Sep-Oct;143(5):337-50. doi: 10.1016/s0923-2516(06)80122-6.

Authors

H Perron¹, B Gratacap, B Lalande, O Genoulaz, A Laurent, C Geny, M Mallaret, P Innocenti, E Schuller, P Stoebner, et al.

Affiliation

¹ UMR 103 CNRS/BioMérieux, Ecole Normale Supérieure de Lyon, France.

PMID: 1282730
DOI: 10.1016/s0923-2516(06)80122-6

Abstract

We have recently isolated an apparently novel retrovirus (LM7) from a patient with multiple sclerosis (MS). We present here results showing that (1) LM7 retrovirus can be transmitted in vitro to a normal human leptomeningeal cell culture and that (2) specific antibody against this retroviral strain can be detected in MS cases. Our results suggest that, if this virus is an endogenous retrovirus, it is different from human endogenous elements already described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral / analysis
Antigens, Viral / analysis
Antigens, Viral / immunology*
Blotting, Western
Cells, Cultured
Humans
Meninges / microbiology*
Microscopy, Electron
Multiple Sclerosis / microbiology*
RNA-Directed DNA Polymerase / metabolism
Radioimmunoprecipitation Assay
Retroviridae / immunology
Retroviridae / isolation & purification
Retroviridae / physiology*
Retroviridae / ultrastructure

Substances

Antibodies, Viral
Antigens, Viral
RNA-Directed DNA Polymerase