Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats

Pain. 2003 Jun;103(3):229-235. doi: 10.1016/S0304-3959(03)00168-4.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology*
  • Analgesics / therapeutic use
  • Animals
  • Antidepressive Agents / pharmacology
  • Antidepressive Agents / therapeutic use
  • Cyclohexanols / pharmacology*
  • Cyclohexanols / therapeutic use
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Enzyme Inhibitors / pharmacology
  • Fenclonine / pharmacology
  • Male
  • Mononeuropathies / drug therapy*
  • Motor Activity / drug effects
  • Naloxone / pharmacology
  • Narcotic Antagonists / pharmacology
  • Pain / drug therapy*
  • Pain Threshold / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Sciatic Nerve / injuries
  • Venlafaxine Hydrochloride
  • Vocalization, Animal / drug effects
  • alpha-Methyltyrosine / pharmacology

Substances

  • Analgesics
  • Antidepressive Agents
  • Cyclohexanols
  • Enzyme Inhibitors
  • Narcotic Antagonists
  • Naloxone
  • alpha-Methyltyrosine
  • Venlafaxine Hydrochloride
  • Fenclonine