Constituents of Eriobotrya japonica. A study of their antiviral properties

J Nat Prod. 1992 Aug;55(8):1067-73. doi: 10.1021/np50086a006.

Abstract

The CHCl3 extract of Eriobotrya japonica from an Italian source was shown to contain four new triterpene esters, namely, 23-trans-p-coumaroyltormentic acid [1], 23-cis-p-coumaroyltormentic acid [2], 3-O-trans-caffeoyltormentic acid [3], and 3-O-trans-p-coumaroylrotundic acid [4], in addition to three common ursolic acid derivatives 5, 6, and 7. An investigation of the antiviral properties of compounds 1-7 revealed that only 3 significantly reduced rhinovirus infection. The compounds were ineffective towards human immunodeficiency virus type 1 (HIV-1) and Sindbis virus replication.

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cells, Cultured
  • Cytopathogenic Effect, Viral / drug effects
  • HIV Reverse Transcriptase
  • HIV-1 / drug effects
  • Magnetic Resonance Spectroscopy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry*
  • RNA Viruses / drug effects
  • Reverse Transcriptase Inhibitors
  • Rhinovirus / drug effects
  • Sindbis Virus / drug effects
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Plant Extracts
  • Reverse Transcriptase Inhibitors
  • HIV Reverse Transcriptase